THELI is an easy-to-use, end-to-end pipeline for the reduction of any optical, near-IR and mid-IR imaging data. It combines a variety of processing algorithms and third party software into a single, homogeneous tool. Over 90 optical and infrared instruments at observatories world-wide are pre-configured; more can be added by the user. The code's online appendix contains three walk-through examples using public data (optical, near-IR and mid-IR) and additional online documentation is available for training and troubleshooting.