KROME, given a chemical network (in CSV format), automatically generates all the routines needed to solve the kinetics of the system modeled as a system of coupled Ordinary Differential Equations. It provides a large set of physical processes connected to chemistry, including photochemistry, cooling, heating, dust treatment, and reverse kinetics. KROME is flexible and can be used for a wide range of astrophysical simulations. The package contains a network for primordial chemistry, a small metal network appropriate for the modeling of low metallicities environments, a detailed network for the modeling of molecular clouds, and a network for planetary atmospheres as well as a framework for the modelling of the dust grain population.