GalCEM (GALactic Chemical Evolution Model) tracks isotope masses as a function of time in a given galaxy. The list of tracked isotopes automatically adapts to the complete set provided by the input yields. The prescription includes massive stars, low-to-intermediate mass stars, and Type Ia supernovae as enrichment channels. Multi-dimensional interpolation curves are extracted from the input yield tables with a preprocessing tool; these interpolation curves improve the computation speeds of the full convolution integrals, which are computed for each isotope and for each enrichment channel. GalCEM also provides tools to track the mass rate change of individual isotopes on a typical spiral galaxy with a final baryonic mass of 5×1010M⊙.