EXOFASTv2 improves upon EXOFAST (ascl:1207.001) for exoplanet modeling. It uses a differential evolution Markov Chain Monte Carlo code to fit an arbitrary number of transits (each with their own error scaling, normalization, TTV, and/or detrending parameters), an arbitrary number of RV sources (each with their own zero point and jitter), and an arbitrary number of planets, changing nothing but command line arguments and configuration files. The global model includes integrated isochrone and SED models to constrain the stellar properties and can accept priors on any fitted or derived quantities (e.g., parallax from Gaia). It is easily extensible to add additional effects or parameters.