The PHANGS-ALMA pipeline process data from radio interferometer observations. It uses CASA (ascl:1107.013), AstroPy (ascl:1304.002), and other affiliated packages to process data from calibrated visibilities to science-ready spectral cubes and maps. The PHANGS-ALMA pipeline offers a flexible alternative to the scriptForImaging script distributed by ALMA. The pipeline runs in two separate software environments: CASA 5.6 or 5.7 (staging, imaging and post-processing) and Python 3.6 or later (derived products) with modern versions of several packages.