JexoSim 2.0 (JWST Exoplanet Observation Simulator) simulates exoplanet transit observations using all four instruments of the James Webb Space Telescope, and is designed for the planning and validation of science cases for JWST. The code generates synthetic spectra that capture the full impact of complex noise sources and systematic trends, allowing for assessment of both accuracy and precision in the final spectrum. JexoSim does not contain all known systematics for the various instruments, but is a good starting point to investigate the effects of systematics, and has the framework to incorporate more systematics in the future.