pygwb analyzes laser interferometer data and designs a gravitational wave background (GWB) search pipeline. Its modular and flexible codebase is tailored to current ground-based interferometers such as LIGO Hanford, LIGO Livingston, and Virgo, but can be generalized to other configurations. It is based on GWpy (ascl:1912.016) and bilby (ascl:1901.011) for optimal integration with widely-used gravitational wave data analysis tools. pygwb also includes a set of scripts to analyze data and perform large-scale searches on a high-performance computing cluster efficiently.