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PyDrizzle provides a semi-automated interface for computing the parameters necessary for running Drizzle (ascl:1212.011). PyDrizzle performs the task of determining the parameters necessary for aligning images based on the WCS information in the input image headers, as well as any supplemental alignment information provided in shift files, and combines the images onto the same WCS. Though it does not identify cosmic rays, it has the ability to ignore pixels flagged as bad, such as pixels identified by other programs as affected by cosmic rays.