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The High-Resolution Imaging and Spectroscopy of Exoplanets (HiRISE) instrument at the Very Large Telescope (VLT) combines the exoplanet imager SPHERE with the high-resolution spectrograph CRIRES using single-mode fibers. HiRISE has been designed to enable the characterization of known, directly-imaged planetary companions in the H band at a spectral resolution on the order of R = λ/∆λ = 140 000. The hipipe package is a custom python pipeline used to reduce the HiRISE data and produce high-level science products that can be used for astrophysical interpretation.