Rosetta runs tasks for resource-intensive, interactive data analysis as software containers. The code's architecture frames user tasks as microservices – independent and self-contained units – which fully support custom and user-defined software packages, libraries and environments. These include complete remote desktop and GUI applications, common analysis environments such as the Jupyter Notebooks. Rosetta relies on Open Container Initiative containers, allowing for safe, effective and reproducible code execution. It can use a number of container engines and runtimes and seamlessly supports several workload management systems, thus enabling containerized workloads on a wide range of computing resources.