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The software framework AMReX is designed for building massively parallel block-structured adaptive mesh refinement (AMR) applications. Key features of AMReX include C++ and Fortran interfaces; 1-, 2- and 3-D support; and support for cell-centered, face-centered, edge-centered, and nodal data. The framework also supports hyperbolic, parabolic, and elliptic solves on hierarchical adaptive grid structure, optional subcycling in time for time-dependent PDEs, and parallelization via flat MPI, OpenMP, hybrid MPI/OpenMP, or MPI/MPI, and parallel I/O. AMReX supports the plotfile format with AmrVis, VisIt (ascl:1103.007), ParaView (ascl:1103.014), and yt (ascl:1011.022).