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MAESTROeX solves the equations of low Mach number hydrodynamics for stratified atmospheres or stars with a general equation of state. It includes reactions and thermal diffusion and can be used on anything from a single core to 100,000s of processor cores with MPI + OpenMP. MAESTROeX maintains the accuracy of its predecessor MAESTRO (ascl:1010.044) while taking advantage of a simplified temporal integration scheme and leveraging the AMReX software framework for block-structured adaptive mesh refinement (AMR) applications.