CRPropa3, an improved version of CRPropa2 (ascl:1412.013), provides a simulation framework to study the propagation of ultra-high-energy nuclei up to iron on their voyage through an (extra)galactic environment. It takes into account pion production, photodisintegration, and energy losses by pair production of all relevant isotopes in the ambient low-energy photon fields, as well as nuclear decay. CRPropa3 can model the deflection in (inter)galactic magnetic fields, the propagation of secondary electromagnetic cascades, and neutrinos for a multitude of scenarios for different source distributions and magnetic environments. It enables the user to predict the spectra of UHECR (and of their secondaries), their composition and arrival direction distribution. Additionally, the low-energy Galactic propagation can be simulated by solving the transport equation using stochastic differential equations. CRPropa3 features a very flexible simulation setup with python steering and shared-memory parallelization.